I obtained my PhD degree in Physics and have developed multiple tools and methods to study bio-matter interfaces. During my Posdoc work I focused on immunoengineering aspects of T-cell activation. I was interested in applying the previously developed tools to important biological applications such as immunotherapy in the context of T-cell activation.
T-cell migration, activation and function are important aspects of immunotherapy and several studies have demonstrated that the microenvironment could strongly influence T-cell response. Previous work from the Klotzsch group had demonstrated that mechanical forces have an impact on dynamics of the sub-cellular system, and may be a critical parameter in T-cell activation too. In our project we aimed to monitor the activity of T-cells as a functional mechanical forces and to study the structural and molecular (genetics) response of the cell to the applied forces.