Dr. Diana Stoycheva


As part of Prof Klotzsch’s lab, I was interested in establishing a T cell activation system for studying the effect of mechanical forces on T cell responses. With the help of super resolution microscopy, we planned to analyze the mechanotransduction of forces in T cells from the T cell receptor to the nucleus. Complementary techniques such as single-cell transcriptomics were implemented to study gene regulation in correlation to force-induced structural changes in living cells. This knowledge and approach is highly motivated by the need for optimized T cell activation and expansion in the context of T-cell based therapeutic strategies.

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